Mann on Main occupies what was once the original seven-story Blass Department Store that was built in 1906. The renovation of the annex building and construction of the parking deck, atop the previous surface lot, completes a three-part re-development project along historic Main Street in downtown Little Rock.  The seven-story building, was designed by architect George Mann and is one of the city's most architecturally significant structures and listed on the National Register of Historic Places. The re-development for the project was made possible due to New Market Tax Credits awarded by the Heartland Renaissance Fund of Little Rock.

Major offices for the State of Arkansas are housed in the building, making them the exclusive tenant and user within Mann on Main. The property also houses state agencies such as the University of Arkansas Partners for Inclusive Communities, Office of Child Support Enforcement, Arkansas Crime Information Center and the Arkansas State Board of Pharmacy. The ground floor offers a large retail component providing additional services and amenities to residents in the community.